Nature Reviews Molecular Cell Biology - Issue - nature.com science feeds

Telomeres: protecting chromosomes against genome instability
by Roderick J. O'SullivanJan Karlseder
3 Feb 2010 at 12:00am
The natural ends of linear chromosomes require unique genetic and structural adaptations to facilitate the protection of genetic material. This is achieved by the sequestration of the telomeric sequence into a protective nucleoprotein cap that masks the ends from constitutive exposure to the DNA damage
Autophagy: Doubling up
by Debbie Walker
3 Feb 2010 at 12:00am
The COG complex directly participates in double-membrane vesicle formation.
Genome instability: Forbidden CIN
by Katharine H. Wrighton
10 Feb 2010 at 12:00am
New insight into how Bub1 and BUBR1 prevent chromosomal instability.
A histone code for DNA repair
by Ralph Scully
10 Feb 2010 at 12:00am
Discovery that radiation induces phosphorylation of histone H2AX.
Signal transduction: Integrin's new partner
by Kim Baumann
10 Feb 2010 at 12:00am
Integrin?G?13 interaction mediates signalling to SRC and RHOA.
Genome destabilization by homologous recombination in the germ line
by Mariko SasakiJulian LangeScott Keeney
18 Feb 2010 at 12:00am
Meiotic recombination, which promotes proper homologous chromosome segregation at the first meiotic division, normally occurs between allelic sequences on homologues. However, recombination can also take place between non-allelic DNA segments that share high sequence identity. Such non-allelic homologous recombination (NAHR) can markedly alter genome architecture
Genome instability: The more, the merrier
by Rachel David
18 Feb 2010 at 12:00am
Ribosomal DNA repeats are essential for maintaining genome integrity.
Gene expression: A new signature for splicing
by Francesca Cesari
18 Feb 2010 at 12:00am
Histone marks regulate alternative splicing.
Mitotic homologous recombination maintains genomic stability and suppresses t...
by Mary Ellen MoynahanMaria Jasin
Mitotic homologous recombination promotes genome stability through the precise repair of DNA double-strand breaks and other lesions that are encountered during normal cellular metabolism and from exogenous insults. As a result, homologous recombination repair is essential during proliferative stages in development and during somatic cell
Maintaining genome stability at the replication fork
by Dana BranzeiMarco Foiani
Aberrant DNA replication is a major source of the mutations and chromosome rearrangements that are associated with pathological disorders. When replication is compromised, DNA becomes more prone to breakage. Secondary structures, highly transcribed DNA sequences and damaged DNA stall replication forks, which then require checkpoint
Repeat instability as the basis for human diseases and as a potential target ...
by Arturo López CastelJohn D. ClearyChristopher E. Pearson
Expansions of repetitive DNA sequences cause numerous human neurological and neuromuscular diseases. Ongoing repeat expansions in patients can exacerbate disease progression and severity. As pathogenesis is connected to repeat length, a potential therapeutic avenue is to modulate disease by manipulating repeat expansion size ? targeting
Genomic instability ? an evolving hallmark of cancer
by Simona NegriniVassilis G. GorgoulisThanos D. Halazonetis
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the mutator hypothesis. In sporadic (non-hereditary) cancers the molecular basis of genomic instability remains unclear, but recent high-throughput
Cell signalling: TMEPAI keeps TGF? under control
by Katharine H. Wrighton
The TGF?-induced protein TMEPAI negatively regulates TGF? signalling.
Gene expression: Beyond pores
by Kim Baumann
Nucleoporins activate developmental and cell cycle genes in D. melanogaster.
In brief
Genome instability

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